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Three-Dimensional Bioprinting & Evaluation of Process-Induced Cell Injury

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报告名称:Three-Dimensional Bioprinting & Evaluation of Process-Induced Cell Injury
时        间:7月2日下午15:00-17:00
地        点:北校区图书馆西裙楼三楼报告厅
报   告   人:Yong Huang, Department of Mechanical & Aerospace Engineering, University of Florida, Gainesville, FL 32611
报告(授课)人介绍:Dr. Yong Huang is a professor of Mechanical Engineering, Biomedical Engineering, & Materials Science & Engineering at the University of Florida,Gainesville, Florida. His research interests are two-fold: processing of biological & engineering materials for healthcare/energy applications & understanding of process-induced damage & defect structures. His current research topics include three-dimensional (3D) printing of biological & engineering structures, precision engineering of medical implants & performance evaluation of machined implants,& fabrication of polymeric microspheres / microcapsules / hollow fiber membranes. He served as the Technical Program Chair for the 2010 American Society of Mechanical Engineers International Manufacturing Science & Engineering Conference (MSEC 2010) & the 2012 International Symposium on Flexible Automation (ISFA 2012). He received various awards for his manufacturing research contributions including the ASME Blackall Machine Tool & Gage Award (2005), the SME Outstanding Young Manufacturing Engineer Award (2006), the NSF CAREER Award (2008), & the ASME International Symposium on Flexible Automation Young Investigator Award (2008). He got his Ph.D. in Mechanical Engineering from the Georgia Institute of Technology in 2002 & is a Fellow of ASME.

报告摘要:Maskless jet-based (including laser- & inkjet-based) three-dimensional (3D) cell printing is a revolutionary advance for printing arbitrary cell patterns as well as creating heterogeneous living constructs. Most importantly, cell printing provides a promising solution to the problem of organ donor shortages by printing 3D tissue/organ constructs for implantation, resulting in what is known as organ printing. Unfortunately, process-induced thermomechanical injury to cells as well as other biomaterials during printing still poses a significant challenge to ensuring a satisfactory post-transfer cell viability. As previous studies show, process-induced thermomechanical loading can dramatically increase the cell mortality rate if printing conditions are not properly selected.

   Using a representative laser cell printing technology (modified laser-induced forward transfer) as a jet-based model system, we have been addressing the aforementioned printing-induced cell injury challenge by studying 1) the process-induced cell thermomechanical loading profiles during the cell droplet formation & landing processes, two key processes during cell printing; 2) the post-transfer cell viability based on the process-induced thermomechanical loading profiles. In this talk, the perspective of ongoing cell printing research is first introduced. Then the modeling of the laser-induced cell droplet formation & successive landing processes & resultant cell mechanical loading is discussed. Finally, the relationship between the post-transfer cell injury/viability & the mechanical loading information is captured through an apoptosis signaling pathway-based modeling approach

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